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FOREWORD
This is the second book in a series of companion pieces
to the bi-annual conferences on Alzheimer’s and Parkinson’s diseases
(AD/PD). The first one was published, also by Medimond, in 2003. This
book contains 42 papers written by selected authors, who had presented
their research at the 7th International Conference on Alzheimer’s and
Parkinson’s Diseases: Clinical and Preclinical Perspectives (AD/PD
2005), that took place on March 9-13, 2005 in enchanting Sorrento, Italy.
The official proceedings (OP) of the Conference will be published early
in 2006 by Springer.
The Sorrento meeting included over 1,300 scientific participants, and
was the venue for several hundred invited talks, general talks, posters,
and symposia. It was impossible to include all of the important
scientific information presented at the meeting under one cover while,
at the same time, meeting publishers’ cost and profit considerations. We,
the co-organizers, therefore decided to restrict contributions to the OP
to chapters based on oral, invited presentations at the meeting.
Medimond has partnered with us to provide an outlet to the many topics
of excellent research presented in Sorrento that, for the above reasons,
are not represented in the OP. This book therefore expands the scope of
available information from the official AD/PD 2005 proceedings that will
follow.
Medimond’s policy is to provide rapid publication of conference
proceedings. Thus, in the interest of saving time and allowing rapid
publication, we agreed with the publishers’ request that we would only
correct major mistakes or errors in scientific logic and fact. We would
not concern ourselves with stylistic differences in expression by
authors whose first language is other than English, nor with differences
in font type, style, or referencing in these chapters. We have also not
been too particular in the choice of chapters that have been included in
the book, in order to encourage diversity in the topics presented. Each
author is solely responsible for the information provided in his/her
chapter, and the subject matter included does not necessarily represent
the concurrence of the editors.
A more thorough and rigid editorial process will be employed in the case
of the OP document.
We trust that this book (and the accompanying CD) will provide the
reader with a broader overview of the breadth and richness of the
program of the AD/PD 2005 conference. In particular, we would like to
thank the authors of the chapters in this book, for their understanding
of the topic-selection dilemma, and for going along with Medimond’s
conditions for publication. The important work of these authors,
presented at AD/PD 2005, thus gets to be expressed as well, and even
sooner than the official document from the conference.
A. Fisher, Ph.D. I. Hanin, Ph.D. F. Stocchi, M.D. M. Memo, Ph.D.
INDEX
The Influence of Genotype on Lipid Parameters in Alzheimer
Disease
L. Fernández-Novoa, V.R.M. Lombardi, S. Seoane, I. Etcheverría, L. Corzo and
R. Cacabelos
Functional and Structural Domains of the 5’–Flanking
Regions of the BACE1 Gene Promoter: Implications in Alzheimer’s Disease
D.K. Lahiri, Y–W. Ge, B. Maloney, G. Thiel, N.H. Zawia, N.H. Greig and K.
Sambamurti
Phosphorylation and Aggregation of Protein Tau in
Humanized Yeast Cells and in Transgenic Mouse Brain
T. Vandebroek, D. Terwel, T. Van Helmont, J. Winderickx and F. Van Leuven
Assembly of Filamentous Aggregates Elicited in Tau
Transfectant M1C by Chloroquine Treatment
T. Hamano, L. Ko, W-L. Lin, M. DeTure and S-H.C. Yen
Components Enhancing a-synuclein Aggregation and Toxicity
in a Humanized Yeast
K. Pellens, P. Zabrocki, T. Vanhelmont, T. Vandebroek, G. Griffioen, S.
Wera, F. Van Leuven and J. Winderickx
A Novel Regulator of Calcium/Calmodulin-Dependent
Signaling
S.V. Rakhilin, P.A. Olson, A. Nishi, N.N. Starkova, A.A. Fienberg, D.J.
Surmeier and A.C. Nairn
Amyloid-b-Peptide Activates the Neuronal c-Abl Tyrosine
Kinase/ p73 Signaling Pathway
A. Alvarez, N. Leal, G. Cancino, P. Castro and K.S. Kosik
A Gamma-Secretase Independent Function of PS1 Links
Cell-Cell Adhesion to AD Pathology; Effects of PS1 FAD Mutations
L. Baki and N.K. Robakis
Multiple in vitro Assays Provide no Evidence for an
Interaction Between hAb1-42 and the ha4b2 nAChR
K. Finlayson, J. Hodgkiss, N. Crawford, J. McLuckie and J. Sharkey
Lysosomal Enhancement with Microbial Hydrolases: A Novel
Strategy for Removing Protein Aggregates
A. de Grey
Lysosomal Modulation and Autophagic Induction:
Compensatory Processes in Response to Protein Deposition Pathology
L. Batey, D.J. Chin, S. Karim, D.A. Karanian, D. Butler and B.A. Bahr
Peroxisomal Proliferation Prevents b-Amyloid
Neurodegeneration
M.J. Santos, R.A. Quintanilla, J.A. Godoy, A. Toro and N.C. Inestrosa
Activation of NF-kB c-Rel Complexes Reduces Neuron
Susceptibility to Amyloid b Peptide
I. Sarnico, F. Boroni, M. Benarese, H-C. Liou, P.F. Spano and M. Pizzi
Development of Inhibitors of Pathological Tau
hyperphosphorylation for a Disease Modifying Approach to Alzheimer’s Disease
H. Sahagún, G. Hübinger, H. Klafki, S. Gordon, S. Ferrand, S. Mühlbacher, S.
Müller, P. Seneci, B. Monse, W. Fröhner, L. Casiraghi, O. Thillaye du
Boullay, T. Braxmeier, S. LeCorre, L. Dirscherl, C. Jolivalt, G. Lahu, I.
Sobek-Klocke, N. Plesnila, M. Hutton and H. Roder
TNF-a Synthesis Inhibitors on the 3-Phthalimidoglutarimide
Backbone as Therapeutic Candidates for Neurodegenerative Diseases
D. Tweedie, T. Giordano, Q.-S. Yu, W. Luo, H.W. Holloway, R.S. Pyle, A.
Brossi, K. Sambamurti, D.K. Lahiri and N.H. Greig
b-amyloid Neurotoxicity Involves TNF-related Apoptosis
Inducing Ligand (TRAIL) Pathway: The Role of Free Radicals
D. Uberti, T. Carsana and M. Memo
Possible Role of the Olfactory System in Alzheimer’s
Disease Genesis
N.V. Bobkova, I.V. Nesterova, N.I. Medvinskaya, I.Y. Aleksandrova, A.N.
Samokhin, J.G. Gershovich, P.M. Gershovich and V.A. Yashin
Effect of Chronic Lithium Treatment in an Animal Model of
Tauopathies
H. Nakashima, T. Ishihara, J.Q. Trojanowski and V.M.-Y. Lee
b-Amyloid and Tau Pathology in the Aged Cynomolgus Monkey
Brain (Macaca fascicularis)
K. Niggemann, R. Brandt, S. Friderichs-Gromoll, G. Habermann, J. Kaspareit
and E. Buse
Modulation of Intracellular Amyloid –b-Peptide Aggregation
by Copper in Caenorhabditis elegans
A. Minniti, P. Grez, C. Opazo, I. Volitakis, R. Cherny, C. Masters, A. Bush
and N. Inestrosa
Searching for an Animal Model for Parkinson’s Disease
Using
TAT-a-Synuclein-A30P
A. Recchia, D. Rota, D. Guidolin, P. Debetto, A. Negro and P. Giusti
Catecholamine-related Enzyme Affecting Behavior
N. Asada
Effects of H1 and H2 Histamine Receptors and Muscarinic
Cholinoceptors on Memory Retention in Rats
M. Eidi and A. Eidi
Effects of Permethrin on Muscarinic Cholinergic Receptors
in Mouse Striatum
Sathaporn Prutipanlai, Sukumal Chongthammakun, Pawinee Piyachaturawat,
Orapin Wongsawatkul, Piyajit Watcharasit and Jutamaad Satayavivad
Effects of Vitamin E and Acetylcholine on Memory Retention
of Passive Avoidance Learning in Rats
A. Eidi, M. Eidi and G. Mahmoodi
Grades of Cognitive Impairments Studied by Dual
Assessments of Elderly Persons
K. Sakamoto, C. Nakayashiki, M. Hida, F. Sakamoto and N. Ishiko
Factors Influencing Caregiver Burden in AD Patients: The
Key Role of Dependency
S. Andrieu, N. Despiegel, C. Guilhaume and B. Vellas
Cachexia of Idiopathic Parkinsonism Disease Viewed as an
Immune/Inflammatory Process
S. Dobbs, J. Dobbs, C. Weller, N. Oxlade, A. Charlett, A. Price, I.
Bjarnason and R. Kerwin
Controlling Hallucinations/Delusion in Patients with
Parkinson’s Disease
K. Hasegawa, E. Horiuchi and H. Kowa
Direct Comparison of Spatially Normalized FDG-PET and
ECD-SPECT Scans in Alzheimer’s Disease and Mild Cognitive Impairment
A. Okumura, S. Fukuyama, J. Shinoda and T. Iwama
Alterations in the Planum Temporale in Patients with
Alzheimer Disease Estimated Via a New Volumetric Method
P. Zach, Z. Kristofiková, E. Majer, P. Selinger and D. Øípová
Rehabilitation of Anosognosia in Patients with Alzheimer’s
Disease: A Pilot Study
M.J. Al Aloucy, Ch. Pélissier, A. Boudebza,
M. Roudier and G. Dalla Barba
Standardized Multiparameter Quantification of Biomarkers
for Alzheimer’s Disease in Cerebrospinal Fluid
H. Vanderstichele, L. Demeyer, K. De Roo, S. Van Remoortere, V. Mortier, A.
Olsson, L. Vandecasteele, V. Kostanjevecki, K. Blennow and E. Vanmechelen
Glutathione S-Transferase P1 (GSTP1) AND Apolipoprotein E
(APOE) Gene Polymorphisms in Parkinson’s Disease
F. Mastaglia, E. Bolitho, F. Van Bockxmeer and M. Garlepp
Dopamine Receptor D2 (DRD2) and COMT Polymorphisms in
Parkinson’s Disease
Y. Lee, E. Bolitho, F. Mastaglia and M. Garlepp
Shift in the BAlance of TRKA and pro-NGF in Prodromal
Alzheimer’s Disease
E.J. Mufson, S.E. Counts, S. Peng and M. Fahnestock
Alteration of Immune Function and Lymphocyte Apoptosis in
Patients with Alzheimer’s Disease (AD)
V.R.M. Lombardi, I. Etcheverría, L. Fernández-Novoa, S. Seoane and R.
Cacabelos
Frontal Variant in PS1 Mutated Families: Does a Pure
Clinical Picture of Alzheimer’s Disease Exist?
G. Puccio, R. Colao, S.A.M. Curcio, F. Frangipane, M. Mirabelli, L. Bernardi,
C. Tomaino, R.G. Maletta, J.F. Foncin and A.C. Bruni
Is Decreased pro-BDNF the Cause of Alzheimer’s-Associated
Neurodegeneration and Cognitive Decline?
M. Fahnestock, S. Peng, D. Garzon and E.J. Mufson
Neurobiological Basis of BPSD in Alzheimer’s Disease
K. Meguro, T. Tomoko, M. Tashiro, Y. Tanaka, H. Ishii and M. Itoh
Ispronicline: Safety, Tolerability, Pharmacokinetics and
Pharmaco EEG Changes in Volunteer Studies
G.C. Dunbar
A “Yang-invigorating” Chinese Herbal Suppository
Preparation Relieves Symptoms in Patients with Parkinson’s Disease
K.M. Ko, K. Chan, L. Shek, J. Yeung and S.H. Chui
True Healing of Alzheimer’s Disease by Holistic
Homoeopathy
D. Patel |
